diff --git a/chrome/browser/ui/views/autofill/popup/popup_base_view.cc b/chrome/browser/ui/views/autofill/popup/popup_base_view.cc
index 269b903884504..6742baf7d4ef0 100644
--- a/chrome/browser/ui/views/autofill/popup/popup_base_view.cc
+++ b/chrome/browser/ui/views/autofill/popup/popup_base_view.cc
@@ -48,6 +48,7 @@
 #include "ui/views/focus/focus_manager.h"
 #include "ui/views/layout/fill_layout.h"
 #include "ui/views/layout/layout_provider.h"
+#include "ui/views/view_tracker.h"
 #include "ui/views/widget/widget.h"
 
 #if DCHECK_IS_ON()
@@ -361,6 +362,11 @@ void PopupBaseView::DoHide() {
 }
 
 void PopupBaseView::NotifyAXSelection(views::View& selected_view) {
+  // Firing a native accessibility event can synchronously re-enter the browser
+  // UI thread (e.g. on Windows, ::UiaRaiseAutomationEvent pumps the COM STA
+  // and may dispatch pending UI-thread tasks). Guard against `selected_view`
+  // being destroyed during that re-entrancy.
+  views::ViewTracker selected_view_tracker(&selected_view);
   if (!is_ax_menu_start_event_fired_) {
     // Fire the menu start event once, right before the first item is selected.
     // By firing these and the matching kMenuEnd events, we are telling screen
@@ -372,6 +378,9 @@ void PopupBaseView::NotifyAXSelection(views::View& selected_view) {
 
     is_ax_menu_start_event_fired_ = true;
   }
+  if (!selected_view_tracker.view()) {
+    return;
+  }
   selected_view.GetViewAccessibility().SetPopupFocusOverride();
 #if DCHECK_IS_ON()
   constexpr auto kDerivedClasses = base::MakeFixedFlatSet<std::string_view>(
diff --git a/chrome/browser/ui/views/passwords/password_generation_popup_view_views.cc b/chrome/browser/ui/views/passwords/password_generation_popup_view_views.cc
index d01d6ea066df3..4c540673727e2 100644
--- a/chrome/browser/ui/views/passwords/password_generation_popup_view_views.cc
+++ b/chrome/browser/ui/views/passwords/password_generation_popup_view_views.cc
@@ -41,6 +41,7 @@
 #include "ui/views/layout/box_layout.h"
 #include "ui/views/metadata/view_factory.h"
 #include "ui/views/vector_icons.h"
+#include "ui/views/view_tracker.h"
 #include "ui/views/widget/widget.h"
 
 namespace {
@@ -365,11 +366,19 @@ void PasswordGenerationPopupViewViews::ButtonSelectionUpdated() {
 
   auto* nudge_password_buttons =
       static_cast<NudgePasswordButtons*>(nudge_password_buttons_view_);
+  // NotifyAXSelection() fires native accessibility events which on Windows can
+  // synchronously pump the COM STA and re-enter the browser UI thread. A
+  // reentrant Show(kEditGeneratedPassword) -> UpdateState() ->
+  // RemoveAllChildViews() can free `nudge_password_buttons` mid-call.
+  views::ViewTracker buttons_tracker(nudge_password_buttons);
   if (controller_->accept_button_selected()) {
     NotifyAXSelection(*nudge_password_buttons->GetAcceptButton());
   } else if (controller_->cancel_button_selected()) {
     NotifyAXSelection(*nudge_password_buttons->GetCancelButton());
   }
+  if (!buttons_tracker.view()) {
+    return;
+  }
   nudge_password_buttons->UpdateFocus(controller_->accept_button_selected());
 }