diff --git a/chrome/browser/ui/views/tabs/tab_strip.cc b/chrome/browser/ui/views/tabs/tab_strip.cc
index e5b530222e4a1..48b5cbecd95b9 100644
--- a/chrome/browser/ui/views/tabs/tab_strip.cc
+++ b/chrome/browser/ui/views/tabs/tab_strip.cc
@@ -385,8 +385,17 @@ class TabStrip::TabDragContextImpl : public TabDragContext,
     views::View::ConvertPointToScreen(view, &screen_location);
 
     // Note: `tab_strip_` can be destroyed during drag, also destroying `this`.
+    // Drag() may enter a nested run loop and re-home the TabDragController to
+    // another window's context, in which case the source window can be closed
+    // (freeing `this`) while the controller stays alive and returns kAlive.
+    // Track our own liveness, not the controller's. Mirrors the guard in
+    // vertical/vertical_tab_drag_handler.cc.
+    auto self = weak_factory_.GetWeakPtr();
     const TabDragController::Liveness drag_controller_alive =
         drag_controller_->Drag(screen_location);
+    if (!self) {
+      return Liveness::kDeleted;
+    }
 
     return drag_controller_alive == TabDragController::Liveness::kAlive
                ? Liveness::kAlive