diff --git a/chrome/browser/ui/views/autofill/popup/popup_row_view.cc b/chrome/browser/ui/views/autofill/popup/popup_row_view.cc
index 333fb65b0ac29..127af192ad961 100644
--- a/chrome/browser/ui/views/autofill/popup/popup_row_view.cc
+++ b/chrome/browser/ui/views/autofill/popup/popup_row_view.cc
@@ -45,6 +45,7 @@
 #include "ui/events/keycodes/keyboard_codes.h"
 #include "ui/events/types/event_type.h"
 #include "ui/gfx/geometry/insets.h"
+#include "ui/views/view_tracker.h"
 #include "ui/gfx/geometry/outsets_f.h"
 #include "ui/gfx/geometry/rect_f.h"
 #include "ui/views/accessibility/view_accessibility.h"
@@ -370,6 +371,10 @@ void PopupRowView::SetSelectedCell(std::optional<CellType> new_cell) {
     controller_->UnselectSuggestion();
   }
 
+  // NotifyAXSelection() can synchronously re-enter the browser thread on
+  // Windows (UIA COM pump) and destroy `*this` via OnSuggestionsChanged().
+  // See popup_base_view.cc and crbug.com/514228954.
+  views::ViewTracker this_tracker(this);
   if ((new_cell == CellType::kControl && expand_child_suggestions_view_) ||
       (new_cell == CellType::kContent && !suggestion_is_acceptable_)) {
     // TODO(crbug.com/370695550): `SetIsSelected()` must go after
@@ -378,6 +383,9 @@ void PopupRowView::SetSelectedCell(std::optional<CellType> new_cell) {
     // moving `SetIsSelected()` into `NotifyAXSelection()` (and rename it) to
     // hide this API complexity from clients.
     GetA11ySelectionDelegate().NotifyAXSelection(*this);
+    if (!this_tracker.view()) {
+      return;
+    }
     GetViewAccessibility().SetIsSelected(true);
     NotifyAccessibilityEventDeprecated(
         ax::mojom::Event::kSelectedChildrenChanged, true);
@@ -386,6 +394,9 @@ void PopupRowView::SetSelectedCell(std::optional<CellType> new_cell) {
     controller_->SelectSuggestion(line_number_);
     content_view_->UpdateStyle(/*selected=*/true);
     GetA11ySelectionDelegate().NotifyAXSelection(*content_view_);
+    if (!this_tracker.view()) {
+      return;
+    }
     content_view_->GetViewAccessibility().SetIsSelected(true);
     NotifyAccessibilityEventDeprecated(
         ax::mojom::Event::kSelectedChildrenChanged, true);
diff --git a/chrome/browser/ui/views/autofill/popup/popup_row_with_button_view.cc b/chrome/browser/ui/views/autofill/popup/popup_row_with_button_view.cc
index fffa5adc19676..3b3acb7a8ec50 100644
--- a/chrome/browser/ui/views/autofill/popup/popup_row_with_button_view.cc
+++ b/chrome/browser/ui/views/autofill/popup/popup_row_with_button_view.cc
@@ -29,6 +29,7 @@
 #include "ui/views/layout/box_layout.h"
 #include "ui/views/metadata/view_factory.h"
 #include "ui/views/view.h"
+#include "ui/views/view_tracker.h"
 #include "ui/views/widget/widget.h"
 
 namespace autofill {
@@ -248,7 +249,13 @@ bool PopupRowWithButtonView::HandleKeyPressEvent(
 }
 
 void PopupRowWithButtonView::SetSelectedCell(std::optional<CellType> cell) {
+  // PopupRowView::SetSelectedCell() -> NotifyAXSelection() can synchronously
+  // re-enter on Windows (UIA COM pump) and free `*this`.
+  views::ViewTracker this_tracker(this);
   autofill::PopupRowView::SetSelectedCell(cell);
+  if (!this_tracker.view()) {
+    return;
+  }
 
   button_->SetVisible(ShouldButtonBeVisible());
 
diff --git a/chrome/browser/ui/views/autofill/popup/popup_view_views.cc b/chrome/browser/ui/views/autofill/popup/popup_view_views.cc
index fa0289fc084b9..c67bed21d4b3e 100644
--- a/chrome/browser/ui/views/autofill/popup/popup_view_views.cc
+++ b/chrome/browser/ui/views/autofill/popup/popup_view_views.cc
@@ -103,6 +103,7 @@
 #include "ui/views/metadata/view_factory.h"
 #include "ui/views/view.h"
 #include "ui/views/view_class_properties.h"
+#include "ui/views/view_tracker.h"
 #include "ui/views/widget/widget.h"
 
 using views::BubbleBorder;
@@ -930,13 +931,18 @@ void PopupViewViews::SetSelectedCell(
 
     row_with_selected_cell_ = cell_index->first;
     PopupRowView& new_selected_row = GetPopupRowViewAt(cell_index->first);
+    // SetSelectedCell() -> NotifyAXSelection() can synchronously re-enter on
+    // Windows (UIA COM pump) and free the row via OnSuggestionsChanged()
+    // -> CreateSuggestionViews() -> RemoveAllChildViews(). The `!controller_`
+    // check below does not catch the OnSuggestionsChanged() path.
+    views::ViewTracker row_tracker(&new_selected_row);
     new_selected_row.SetSelectedCell(cell_index->second);
-    new_selected_row.ScrollViewToVisible();
-
-    if (!controller_) {
-      // The previous SetSelectedCell() call may have hidden the popup.
+    if (!row_tracker.view() || !controller_) {
+      // The previous SetSelectedCell() call may have hidden the popup or
+      // rebuilt the suggestion rows.
       return;
     }
+    new_selected_row.ScrollViewToVisible();
     const Suggestion& suggestion =
         controller_->GetSuggestionAt(cell_index->first);