diff --git a/chrome/browser/ui/web_applications/tabbed_web_app_navigation_throttle.cc b/chrome/browser/ui/web_applications/tabbed_web_app_navigation_throttle.cc
index 5d6ba6d779be9..4d8521ec004ab 100644
--- a/chrome/browser/ui/web_applications/tabbed_web_app_navigation_throttle.cc
+++ b/chrome/browser/ui/web_applications/tabbed_web_app_navigation_throttle.cc
@@ -4,6 +4,8 @@
 
 #include "chrome/browser/ui/web_applications/tabbed_web_app_navigation_throttle.h"
 
+#include "base/functional/bind.h"
+#include "base/task/sequenced_task_runner.h"
 #include "chrome/browser/profiles/profile.h"
 #include "chrome/browser/ui/browser_window/public/browser_window_interface.h"
 #include "chrome/browser/ui/tabs/tab_strip_model.h"
@@ -137,7 +139,18 @@ TabbedWebAppNavigationThrottle::WillStartRequest() {
     if (browser_window->GetTabStripModel()->count() > 1 &&
         !web_contents->GetLastCommittedURL().is_valid()) {
       DVLOG(1) << "TabbedWebAppNavigationThrottle: Closing blank tab";
-      web_contents->ClosePage();
+      // ClosePage() can synchronously destroy `web_contents` (e.g. when the
+      // primary main frame's renderer is not live or the page is otherwise
+      // ready to be closed), which in turn destroys this throttle. Per the
+      // NavigationThrottle contract, defer the destruction.
+      base::SequencedTaskRunner::GetCurrentDefault()->PostTask(
+          FROM_HERE, base::BindOnce(
+                         [](base::WeakPtr<content::WebContents> contents) {
+                           if (contents) {
+                             contents->ClosePage();
+                           }
+                         },
+                         web_contents->GetWeakPtr()));
     }
     DVLOG(1) << "TabbedWebAppNavigationThrottle: Redirecting to FocusHomeTab";
     return FocusHomeTab(*app_controller, *browser_window->GetTabStripModel());