diff --git a/third_party/blink/renderer/platform/widget/input/widget_base_input_handler.cc b/third_party/blink/renderer/platform/widget/input/widget_base_input_handler.cc
index 3ad3e9f40ec73..cfb5bd208d71b 100644
--- a/third_party/blink/renderer/platform/widget/input/widget_base_input_handler.cc
+++ b/third_party/blink/renderer/platform/widget/input/widget_base_input_handler.cc
@@ -407,6 +407,21 @@ void WidgetBaseInputHandler::HandleInputEvent(
     prevent_default = prevent_default || suppress;
   }
 
+  // WillHandleMouseEvent / WillHandleGestureEvent above can run script (e.g.
+  // cursor_control gestures call MoveCaretSelection which can synchronously
+  // dispatch focus/blur events) which may destroy this WidgetBase via a nested
+  // event loop. Bail out before touching any members.
+  if (!weak_self) {
+    if (callback) {
+      std::move(callback).Run(
+          prevent_default ? mojom::blink::InputEventResultState::kConsumed
+                          : mojom::blink::InputEventResultState::kNotConsumed,
+          swap_latency_info, std::move(handling_state.event_overscroll()),
+          std::move(handling_state.touch_action()));
+    }
+    return;
+  }
+
   WebInputEventResult processed = prevent_default
                                       ? WebInputEventResult::kHandledSuppressed
                                       : WebInputEventResult::kNotHandled;